Hydrochloric Acid → 1-(4-((4-Ethoxyphenyl)ethynyl)phenyl)propan-2-amine hydrochloride

HRID 76172

반응식

HRID 76172 반응식
[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]#[C:11][C:12]2[CH:17]=[CH:16][C:15]([CH2:18][CH:19]([NH:21]C(=O)OC(C)(C)C)[CH3:20])=[CH:14][CH:13]=2)=[CH:6][CH:5]=1)[CH3:2].[ClH:29]>CO>[ClH:29].[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]#[C:11][C:12]2[CH:13]=[CH:14][C:15]([CH2:18][CH:19]([NH2:21])[CH3:20])=[CH:16][CH:17]=2)=[CH:6][CH:5]=1)[CH3:2]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 66611490Tert-butyl 1-(4-((4-ethoxyphenyl)ethynyl)phenyl)propan-2-yl-carbamate

생성물 1

HCID 666106811-(4-((4-Ethoxyphenyl)ethynyl)phenyl)propan-2-amine hydrochloride

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
70 °C

실험 절차

To 3.30 g (8.70 mmol) tert-butyl 1-(4-((4-ethoxyphenyl)ethynyl)phenyl)propan-2-yl-carbamate (I60) in 40 mL MeOH are added 20 mL (25 mmol) HCl (1.25M in MeOH). The mixture is stirred at 70° C. for 7 h. The solvent is removed in vacuo and the crude product is triturated with DIPE and dried in normal atmosphere.

후처리

  1. customThe solvent is removed in vacuo
  2. customthe crude product is triturated with DIPE
  3. customdried in normal atmosphere

출처 및 근거

ORD 기록
ord-9977905a0b844ee4aae5f5837004ce90
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08835472B2

연결된 노트

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