홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Diisopropylamine → Thiazole-5-carboxylic acid (2-(4-(2-cyclobutoxy-pyrimidin-5-ylethynyl)-phenyl)-1-methyl-ethyl)-amide

HRID 76208
노트
인쇄 미리보기

반응식

HRID 76208 반응식
I[C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH:9]([NH:11][C:12]([C:14]2[S:18][CH:17]=[N:16][CH:15]=2)=[O:13])[CH3:10])=[CH:4][CH:3]=1.C(NC(C)C)(C)C.[CH:26]1([O:30][C:31]2[N:36]=[CH:35][C:34]([C:37]#[CH:38])=[CH:33][N:32]=2)[CH2:29][CH2:28][CH2:27]1>Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.[Cu]I.C1COCC1>[CH:26]1([O:30][C:31]2[N:32]=[CH:33][C:34]([C:37]#[C:38][C:2]3[CH:7]=[CH:6][C:5]([CH2:8][CH:9]([NH:11][C:12]([C:14]4[S:18][CH:17]=[N:16][CH:15]=4)=[O:13])[CH3:10])=[CH:4][CH:3]=3)=[CH:35][N:36]=2)[CH2:27][CH2:28][CH2:29]1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 3

HCID 7912DiisopropylamineHCID 66611343HCID 66611343, 화합물HCID 866696272-Cyclobutoxy-5-ethynyl-pyrimidine

생성물 1

HCID 66611254Thiazole-5-carboxylic acid (2-(4-(2-cyclobutoxy-pyrimidin-5-ylethynyl)-phenyl)-1-methyl-ethyl)-amide

시약·촉매·용매 3

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)촉매
HCID 178418476
HCID 178418476, 화합물
촉매
HCID 8028Tetrahydrofuran용매

반응 조건

온도
0 °C

실험 절차

100 mg (0.27 mmol) thiazole-5-carboxylic acid (2-(4-iodophenyl)-1-methylethyl)-amide (I76) are added to 2.0 mL THF and cooled down to 0° C. 2.87 mg (4.00 μmol) bis(triphenylphosphine)palladium dichloride, 1.02 mg (5.00 μmol) CuI, 90.6 μL (0.65 mmol) diisopropylamine and finally 51.5 mg 2-cyclobutoxy-5-ethynyl-pyrimidine (I25.7) are added and the reaction mixture is stirred at r.t. over night. The solvent is removed in vacuo and the residue is dissolved in EtOAc and washed with diluted ammonia solution (1×) and water (2×). The organic layer is dried with MgSO4 and the solvent is removed in vacuo. The crude product is purified by HPLC (MeOH/H2O/TFA).

후처리

  1. customThe solvent is removed in vacuo
  2. dissolutionthe residue is dissolved in EtOAc
  3. washwashed with diluted ammonia solution (1×) and water (2×)
  4. dry with materialThe organic layer is dried with MgSO4
  5. customthe solvent is removed in vacuo
  6. customThe crude product is purified by HPLC (MeOH/H2O/TFA)

출처 및 근거

ORD 기록
ord-0913b4b2d62a4d428a2cb55c04ee9ed9
출처 데이터셋
uspto-grants-2014_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08835472B2

반응 노트

불러오는 중…

이 페이지에서참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트