Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → HCID 178418938, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 2,4,6-Trichloropyrimidine | HCID 77378 | — |
| 반응물 | 3-cyclopropyl-1H-pyrazol-5-amine | HCID 2758014 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | HCID 178418938 | HCID 178418938 | 80% |
반응 단계
To a solution of-2,4,6-trichloropyrimidine (600 mg, 3.27 mmol) and 3-amino-5-cyclopropylpyrazole (403 mg, 3.27 mmol) in EtOH (10 mL) was added triethylamine (456 μL, 3.27 mmol) and the reaction mixture was stirred for 15 hours at room temperature. The solvent was evaporated and the residue was purified by flash chromatography (SiO2, Hexane/AcOEt gradient) to afford (5-cyclopropyl-2H-pyrazol-3-yl-)-(2,6-dichloropyrimidin-4-yl)-amine (705 mg, 80%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07087603B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-35c861d6b82946f599930c0c25b7c1b1 |
| 출처 메모 | uspto-grants-2006_08 |