Triethylamine → Ethyl N-(4-chloro-2-pyrimidinyl)-N-methylglycinate

HRID 7632

반응식

HRID 7632 반응식
Cl[C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[CH:4][N:3]=1.[CH3:9][NH:10][CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13].C(N(CC)CC)C>O1CCOCC1>[Cl:8][C:6]1[CH:5]=[CH:4][N:3]=[C:2]([N:10]([CH3:9])[CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[N:7]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 775312,4-DichloropyrimidineHCID 95849Glycine, N-methyl-, ethyl ester

생성물 1

HCID 12056459Ethyl N-(4-chloro-2-pyrimidinyl)-N-methylglycinate

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

30.0 g (0.20 mol) of 2,4-dichloropyrimidine, 30.9 g (0.20 mol) of ethyl N-methylglycinate and 61.0 g (0.60 mol) of triethylamine in 200 ml of dioxane are stirred at 50° C. for 10 min. The mixture is filtered off with suction and the mother liquor is concentrated to half the original volume. A solid crystallizes out, which is filtered off with suction. The mother liquor is concentrated, the residue is stirred with petroleum ether and the product is filtered off.

후처리

  1. filtrationThe mixture is filtered off with suction
  2. concentrationthe mother liquor is concentrated to half the original volume
  3. customA solid crystallizes out, which
  4. filtrationis filtered off with suction
  5. concentrationThe mother liquor is concentrated
  6. filtrationthe product is filtered off

출처 및 근거

ORD 기록
ord-8cdd1682398d44799c23b12882d311f3
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087616B2

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