Potassium Carbonate → 5-[4-Chloro-6-(4-methyl-benzylamino)-[1,3,5]-triazin-2-ylamino]-3-methyl-imidazolidine-2,4-dione

HRID 76337

반응식

HRID 76337 반응식
Cl[C:2]1[N:7]=[C:6]([Cl:8])[N:5]=[C:4]([NH:9][CH:10]2[NH:14][C:13](=[O:15])[N:12]([CH3:16])[C:11]2=[O:17])[N:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH3:24][C:25]1[CH:32]=[CH:31][C:28]([CH2:29][NH2:30])=[CH:27][CH:26]=1>CN(C)C=O.O.C(OCC)(=O)C>[Cl:8][C:6]1[N:7]=[C:2]([NH:30][CH2:29][C:28]2[CH:31]=[CH:32][C:25]([CH3:24])=[CH:26][CH:27]=2)[N:3]=[C:4]([NH:9][CH:10]2[NH:14][C:13](=[O:15])[N:12]([CH3:16])[C:11]2=[O:17])[N:5]=1

참가 물질

7

반응물 3

HCID 11430Potassium CarbonateHCID 660354-MethylbenzylamineHCID 866980675-(4,6-Dichloro-[1,3,5]triazin-2-ylamino)-3-methyl-imidazolidine-2,4-dione

생성물 1

HCID 866980665-[4-Chloro-6-(4-methyl-benzylamino)-[1,3,5]-triazin-2-ylamino]-3-methyl-imidazolidine-2,4-dione

시약·촉매·용매 3

HCID 962Water용매HCID 6228Dimethylformamide용매HCID 8857Ethyl Acetate용매

실험 절차

To a stirred suspension of 5-(4,6-dichloro-[1,3,5]triazin-2-ylamino)-3-methyl-imidazolidine-2,4-dione (Example 1.3, Part D) (200 mg, 0.72 mmol) and potassium carbonate (219 mg, 1.59 mmol) in dimethylformamide (5 mL) at room temperature was added 4-methyl-benzylamine (0.1 mL, 0.79 mmol). The reaction mixture was stirred at 35° for 24 h and then diluted with water and ethyl acetate. The ethyl acetate layer was separated, dried and evaporated to give the crude product which was used directly in the next step.

후처리

  1. customThe ethyl acetate layer was separated
  2. customdried
  3. customevaporated

출처 및 근거

ORD 기록
ord-5ddbdf7a5b7e43f8b9d86a7bce001542
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08835629B2

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