Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Butanoic acid, 2-bromo-, ethyl ester → 8-bromo-2-ethyl-2H-benzo[b][1,4]oxazin-3(4H)-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Butanoic acid, 2-bromo-, ethyl ester | HCID 79039 | — |
| 반응물 | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| 반응물 | 2-Amino-6-bromophenol | HCID 15531506 | — |
| 용매 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 생성물 | 8-bromo-2-ethyl-2H-benzo[b][1,4]oxazin-3(4H)-one | HCID 66715230 | 71% |
반응 단계
Procedure & NMR Data: 1.5 g (7.9 mmol) of 2-bromo-6-aminophenol, 1.08 ml (0.9 eq, 7.11 mmol) of 1.8-diazabicyclo[5.4.0]undec-7-ene and 3.5 mL of DL-Ethyl 2-bromobutyrate (3 eq, 23.7 mmol)) in 30 mL of 1-Methyl-2-pyrrolidinone were mixed. 1.447 g of P1 were obtained, yield 71%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08835628B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-efd9c31ad02147a0b0605978b604591c |
| 출처 메모 | uspto-grants-2014_09 |