Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → N-(2,2-difluoroethyl)-2-nitroaniline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 1-Chloro-2-nitrobenzene | HCID 6945 | — |
| 반응물 | 2,2-Difluoroethanamine | HCID 136274 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | N-(2,2-difluoroethyl)-2-nitroaniline | HCID 58110950 | 95% |
반응 단계
2 ml (19 mM) of 2-Chloronitrobenzene and 2.7 ml (36 mM) of 2,2-difluoroethyl amine in 2 ml of acetonitrile were refluxed under stirring for 24 h. Water was added and the aqueous layer was extracted with ethyl acetate. The organic layer was washed with water and dried over anhydrous sodium sulfate. The solvent was removed under vacuum to give 3.65 g of N-(2,2-difluoroethyl)-2-nitroaniline as an orange solid. Yield: 95%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08835634B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-7d277d5a0c004e918e97e3f25455b131 |
| 출처 메모 | uspto-grants-2014_09 |