2-[2-(9H-carbazol-1-ylamino)phenyl]propan-2-ol → 7,7-dimethyl-12,13-dihydro-7H-indolo[3,2-c]acridine

HRID 76380노트

반응식

HRID 76380 반응식
[C:1]1([NH:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[C:21](O)([CH3:23])[CH3:22])[C:13]2[NH:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1>O>[CH3:22][C:21]1([CH3:23])[C:2]2[CH:3]=[CH:4][C:5]3[C:6]4[CH:7]=[CH:8][CH:9]=[CH:10][C:11]=4[NH:12][C:13]=3[C:1]=2[NH:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]1=2

참가 물질

3

반응물 1

HCID 674045002-[2-(9H-carbazol-1-ylamino)phenyl]propan-2-ol

생성물 1

HCID 674033727,7-dimethyl-12,13-dihydro-7H-indolo[3,2-c]acridine

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
0 °C

실험 절차

63 g (200 mmol) of 2-[2-(9H-carbazol-1-ylamino)phenyl]propan-2-ol are initially introduced in 268 g (2734 mmol) of polyphosphoric acid under protective gas and cooled to 0° C. The mixture is subsequently stirred at 100° C. for 3 h and then cooled to room temperature. Water is added to the mixture with ice cooling, the mixture is extracted with ethyl acetate, and the solvent is removed in vacuo. The content of product according to 1H-NMR is about 96% with an overall yield of 53 g (90%).

후처리

  1. temperaturecooled to room temperature
  2. extractionthe mixture is extracted with ethyl acetate
  3. customthe solvent is removed in vacuo

출처 및 근거

ORD 기록
ord-6cee9cc7d498451f963df8108bf9e05c
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08835626B2

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