Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Benzyloxyaniline → N2,N4-bis(3-benzyloxyphenyl)-5-fluoro-2,4-pyrimidinediamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Benzyloxyaniline | HCID 92892 | — |
| 반응물 | 2,4-Dichloro-5-fluoropyrimidine | HCID 250705 | — |
| 생성물 | N2,N4-bis(3-benzyloxyphenyl)-5-fluoro-2,4-pyrimidinediamine | HCID 22060851 | — |
반응 단계
In like manner to the preparation of N2,N4-bis(3-hydroxyphenyl)-5-fluoro-2,4-pyrimidinediamine, 2,4-dichloro-5-fluoropyrimidine and 3-benzyloxyaniline were reacted to yield N2,N4-bis(3-benzyloxyphenyl)-5-fluoro-2,4-pyrimidinediamine. 1H NMR (CDCl3): δ 7.98 (bs, 1H), 7.42-6.99 (m, 16H), 6.75 (d, 1H, J=2.4 Hz), 6.71 (m, 1H), 6.60 (dd, 1H, J=2.4 and 8.4 Hz), 6.32 (m, 1H), 4.97 (s, 2H), 4.94 (s, 2H); LCMS: ret. time: 32.56 min.; purity: 98%; MS (m/e): 493 (MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08835430B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-be3121e07bcf433da8c58b882c99d832 |
| 출처 메모 | uspto-grants-2014_09 |