4-Aminoacetanilide → N2,N4-bis-(4-acetamidophenyl)-5-fluoro-2,4-pyrimidinediamine

HRID 76496

반응식

HRID 76496 반응식
Cl[C:2]1[N:7]=[C:6](Cl)[C:5]([F:9])=[CH:4][N:3]=1.[C:10]([NH:13][C:14]1[CH:20]=[CH:19][C:17]([NH2:18])=[CH:16][CH:15]=1)(=[O:12])[CH3:11]>>[C:10]([NH:13][C:14]1[CH:20]=[CH:19][C:17]([NH:18][C:2]2[N:7]=[C:6]([NH:18][C:17]3[CH:16]=[CH:15][C:14]([NH:13][C:10](=[O:12])[CH3:11])=[CH:20][CH:19]=3)[C:5]([F:9])=[CH:4][N:3]=2)=[CH:16][CH:15]=1)(=[O:12])[CH3:11]

참가 물질

3

반응물 2

HCID 312304-AminoacetanilideHCID 2507052,4-Dichloro-5-fluoropyrimidine

생성물 1

HCID 22060422N2,N4-bis-(4-acetamidophenyl)-5-fluoro-2,4-pyrimidinediamine

실험 절차

In like manner to the preparation of N2,N4-bis(3-hydroxyphenyl)-5-fluoro-2,4-pyrimidinediamine, the reaction of 2,4-dichloro-5-fluoropyrimidine with 4-acetamidoaniline gave N2,N4-bis-(4-acetamidophenyl)-5-fluoro-2,4-pyrimidinediamine. LCMS: ret. time: 14.82 min.; purity: 95%; MS (m/e): 395 (MH+); 1H NMR (DMSO-d6): δ 10.33 (1H, s), 10.14 (1H, s), 10.07 (2H, s), 8.39 (1H, d, J=5.1 Hz), 7.64 (8H, m), 2.15 (3H, s), 2.13 (3H, s).

후처리

  1. customIn like manner to the preparation of N2,N4-bis(3-hydroxyphenyl)-5-fluoro-2,4-pyrimidinediamine

출처 및 근거

ORD 기록
ord-eed6a4ab69604eccb75771b31f609993
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08835430B2

연결된 노트

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