Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Furfurylamine → N2,N4-bis(furfuryl)-5-fluoro-2,4-pyrimidinediamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Furfurylamine | HCID 3438 | — |
| 반응물 | 2,4-Dichloro-5-fluoropyrimidine | HCID 250705 | — |
| 반응물 | R-112 | HCID 9904854 | — |
| 생성물 | N2,N4-bis(furfuryl)-5-fluoro-2,4-pyrimidinediamine | HCID 22060499 | — |
반응 단계
In a manner similar to the preparation of N2,N4-bis(3-hydroxyphenyl)-5-fluoro-2,4-pyrimidinediamine, 2,4-dichloro-5-fluoropyrimidine and furfurylamine were reacted to yield N2,N4-bis(furfuryl)-5-fluoro-2,4-pyrimidinediamine. 1H NMR (CDCl3): δ 7.72 (bs, 1H), 7.38 (dd, 2H, J=1.8 and 7.5 Hz), 6.34-6.30 (m, 2H), 6.22 (dd, 2H, J=2.4 and 9.9 Hz), 5.163 (bs, 2H), 4.63 (d, 2H, J=6.0), 4.54 (d, 2H, J=6.0); 19F NMR (CDCl3): −48621; LCMS: ret. time: 97.27 min.; purity: 97%; MS (m/e): 289 (MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08835430B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-da04fee5eca644c3a5ef98cd3eb09bcd |
| 출처 메모 | uspto-grants-2014_09 |