Methanol → Methyl p-aminosalicylate

HRID 76646

반응식

HRID 76646 반응식
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([OH:11])[CH:3]=1.[CH3:12]O>>[OH:11][C:4]1[CH:3]=[C:2]([CH:10]=[CH:9][C:5]=1[C:6]([O:8][CH3:12])=[O:7])[NH2:1]

참가 물질

3

반응물 2

HCID 887MethanolHCID 46494-Aminosalicylic Acid

생성물 1

HCID 77787Methyl p-aminosalicylate

실험 절차

A solution of 4-amino-2-hydroxybenzoic acid (1 g, 6.5 mmol) in MeOH (15 mL) and concentrated sulfonic acid (1 mL) was refluxed overnight. The reaction mixture was quenched with NaHCO3 aqueous solution (60 mL) and EtOAc (60 mL). The organic layer was separated, dried, evaporated to give 3-hydroxy-4-methoxycarbonylaniline.

후처리

  1. customThe reaction mixture was quenched with NaHCO3 aqueous solution (60 mL) and EtOAc (60 mL)
  2. customThe organic layer was separated
  3. customdried
  4. customevaporated

출처 및 근거

ORD 기록
ord-e159ba31816b4b928b6553cecf01fe6b
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08835430B2

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