Sodium Sulfate → Methyl 4-amino-o-anisate

HRID 76650

반응식

HRID 76650 반응식
[CH3:1][O:2][C:3]1[CH:12]=[C:11]([N+:13]([O-])=O)[CH:10]=[CH:9][C:4]=1[C:5]([O:7][CH3:8])=[O:6].[O-]S([O-])(=O)=O.[Na+].[Na+]>CO.[Pd]>[NH2:13][C:11]1[CH:10]=[CH:9][C:4]([C:5]([O:7][CH3:8])=[O:6])=[C:3]([O:2][CH3:1])[CH:12]=1

참가 물질

5

반응물 2

HCID 24436Sodium SulfateHCID 10798535Methyl 2-methoxy-4-nitrobenzoate

생성물 1

HCID 168705Methyl 4-amino-o-anisate수율 100.3%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

The hydrogenation of methyl 2-methoxy-4-nitrobenzoate (700 mg, 3.3 mmol) in methanol (10 mL) catalyzed by 5% Pd—C (100 mg) and Na2SO4 (100 mg) at 50 psi for 1 h gave methyl 4-amino-2-methoxybenzoate (600 mg, quant.) as a white solid.

출처 및 근거

ORD 기록
ord-291ccf0f56bf4b08a8b320f9ee99d538
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08835430B2

연결된 노트

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