참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Iodoethane | HCID 6340 | — |
| 반응물 | 1,3-Dibromobenzene | HCID 7927 | — |
| 반응물 | Ammonium Chloride | HCID 25517 | — |
| 반응물 | Lithium diisopropylamide | HCID 2724682 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 1,3-Dibromo-2-ethylbenzene | HCID 14847806 | — |
반응 단계
A three necked round-bottom flask was purged with argon and then filled with dry THF (1.2 l), 1,3-dibromo benzene (121 g, 0.514 mol) and ethyl iodide (95.4 g, 0.611 mol). The mixture was cooled to −78° C. and LDA (64.2 g, 0.697 mol) (2 M in THF/n-heptane/ethyl benzene) was added slowly in a way that the temperature did not rise above −65° C. After stirring for 2.75 h the reaction was poured onto 1 l sat. aq. NH4Cl solution and stirred vigorously for 20 min. Two times extraction with DCM yielded colorless oil (167 g) which was used in the next step without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08835653B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_09 |
|---|
| ORD ID | ord-07d968876b81431686c441504a41308c |
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| 출처 메모 | uspto-grants-2014_09 |
|---|
