3,5-Dimethoxyphenol → 3-(4,6-Dimethoxy-1-benzofuran-2-yl)-2,6-dimethoxypyridine

HRID 76824

반응식

HRID 76824 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5](O)[CH:6]=[C:7]([O:9][CH3:10])[CH:8]=1.Br[CH2:13][C:14]([C:16]1[C:17]([O:24][CH3:25])=[N:18][C:19]([O:22][CH3:23])=[CH:20][CH:21]=1)=[O:15]>>[CH3:1][O:2][C:3]1[C:4]2[CH:13]=[C:14]([C:16]3[C:17]([O:24][CH3:25])=[N:18][C:19]([O:22][CH3:23])=[CH:20][CH:21]=3)[O:15][C:5]=2[CH:6]=[C:7]([O:9][CH3:10])[CH:8]=1

참가 물질

3

반응물 2

HCID 103833,5-DimethoxyphenolHCID 860961262-Bromo-1-(2,6-dimethoxypyridin-3-yl)ethanone

생성물 1

HCID 545908713-(4,6-Dimethoxy-1-benzofuran-2-yl)-2,6-dimethoxypyridine수율 53%

실험 절차

This compound was prepared using Method A from 3,5-dimethoxyphenol and 2-bromo-1-(2,6-dimethoxypyridin-3-yl)ethanone: Yield 53% following procedure A.2; m.p. 155-156° C.; IR 2937, 2961, 1605, 1504, 1475, 1460, 1272, 1107, 1011 cm−1; 1H-NMR (500 MHz, δ ppm, CDCl3) 8.12 (d, J=8.2 Hz, 1H), 7.18 (s, 1H), 6.66 (s, 1H), 6.41 (d, J=8.2 Hz, 1H), 6.32 (s, 1H), 4.10 (s, 3H), 3.96 (s, 3H), 3.93 (s, 3H), 3.85 (s, 3H); 13C-NMR (126 MHz, δ ppm, CDCl3) 161.9, 159.1, 158.7, 155.9, 153.7, 149.7, 137.4, 113.9, 106.7, 101.7, 101.5, 94.3, 88.4, 55.9, 55.8, 53.8, 53.7.

후처리

  1. customThis compound was prepared

출처 및 근거

ORD 기록
ord-22e53e505ae5499b983439aeb0ab802d
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08835659B2

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