3,5-Dimethoxyphenol → 2-(4-Fluorophenyl)-1-benzofuran-4,6-diol

HRID 76829

반응식

HRID 76829 반응식
C[O:2][C:3]1[CH:4]=[C:5](O)[CH:6]=[C:7]([O:9]C)[CH:8]=1.Br[CH2:13][C:14]([C:16]1[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=1)=[O:15]>>[F:22][C:19]1[CH:20]=[CH:21][C:16]([C:14]2[O:15][C:5]3[C:6](=[C:7]([OH:9])[CH:8]=[C:3]([OH:2])[CH:4]=3)[CH:13]=2)=[CH:17][CH:18]=1

참가 물질

3

반응물 2

HCID 103833,5-DimethoxyphenolHCID 967492-Bromo-1-(4-fluorophenyl)ethan-1-one

생성물 1

HCID 545909592-(4-Fluorophenyl)-1-benzofuran-4,6-diol수율 80%

실험 절차

This compound was prepared using Method A from 3,5-dimethoxyphenol and 2-bromo-1-(4-fluorophenyl)ethanone: Yield 80% following procedures A.2 and A.5; m.p. 189-190° C.; IR 3332, 1614, 1500, 1243, 1125, 1072 cm−1; 1H-NMR (500 MHz, δ ppm, DMSO-d6) 9.85 (s, 1H), 9.36 (s, 1H), 7.82 (dd, J=8.7 Hz, 5.4 Hz, 2H), 7.27 (t, J=8.9 Hz, 2H), 7.21 (s, 1H), 6.42 (s, 1H), 6.19 (d, J=1.7 Hz, 1H); 13C-NMR (126 MHz, δ ppm, CD3OD) 163.85 (d, J=246.0 Hz), 158.8, 158.0, 153.3, 152.5, 129.0 (d, J=3.3 Hz), 127.1 (d, J=8.1 Hz), 116.8 (d, J=22.2 Hz), 112.9, 99.7, 98.9, 90.9.

후처리

  1. customThis compound was prepared

출처 및 근거

ORD 기록
ord-68eb7d9694b84ad5837db160a380e451
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08835659B2

연결된 노트

불러오는 중…