Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzoyl Peroxide → 2-[4-(Bromomethyl)-3-(trifluoromethyl)phenyl]-1,3-benzoxazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzoyl Peroxide | HCID 7187 | — |
| 반응물 | N-bromobutanimide | HCID 67184 | — |
| 반응물 | 2-[4-Methyl-3-(trifluoromethyl)phenyl]-1,3-benzoxazole | HCID 21990984 | — |
| 용매 | Carbon Tetrachloride | HCID 5943 | — |
| 생성물 | 2-[4-(Bromomethyl)-3-(trifluoromethyl)phenyl]-1,3-benzoxazole | HCID 21990977 | — |
반응 단계
A mixture of 2-[4-methyl-3-(trifluoromethyl)phenyl]-1,3-benzoxazole (600 mg, 2.2 mmol), n-bromosuccinimide (579 mg, 3.25 mmol), benzoyl peroxide (26 mg, 0.11 mmol) in carbon tetrachloride (15 mL) was refluxed for 3 h and then cooled to rt. The white precipitate was filtered and the filtrate was concentrated to dryness. The crude was purified by flash chromatography on silica gel eluting with EtOAc:hexanes (1:1) to afford 2-[4-(bromomethyl)-3-(trifluoromethyl)phenyl]-1,3-benzoxazole.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07087601B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-c265964bdeeb4ce9a2b40b477a9f2b81 |
| 출처 메모 | uspto-grants-2006_08 |