Ethanol → Ethyl 2-(3-fluorophenyl)acetate

HRID 76966

반응식

HRID 76966 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([OH:11])=[O:10])[CH:5]=[CH:6][CH:7]=1.OS(O)(=O)=O.[CH2:17](O)[CH3:18]>>[F:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([O:11][CH2:17][CH3:18])=[O:10])[CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 676173-Fluorophenylacetic acid

생성물 1

HCID 11735538Ethyl 2-(3-fluorophenyl)acetate수율 85%

실험 절차

To a solution of 3-fluorophenyl acetic acid (10.0 g, 64.9 mmol) in ethanol (300 mL), is added a catalytic amount of H2SO4 (98%, 1 mL) and the mixture reacted for 12 hours at 100° C. (LC-MS monitoring: complete conversion). The solvent is evaporated and the residue is partitioned between EtOAc and water; the organic layer is separated and dried over Na2SO4 in order to obtain 10.1 g of (I8) as a white solid (85% yield).

후처리

  1. customthe mixture reacted for 12 hours at 100° C. (LC-MS monitoring: complete conversion)
  2. customThe solvent is evaporated
  3. customthe residue is partitioned between EtOAc and water
  4. customthe organic layer is separated
  5. dry with materialdried over Na2SO4 in order

출처 및 근거

ORD 기록
ord-38049ee9739249dfa2ee123b242c4d2b
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08835682B2

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