참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | m-Aminoacetanilide | HCID 7604 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | Ethyl bromophenylacetate | HCID 97780 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | (3-Acetylamino-phenylamino)-phenyl-acetic acid ethyl ester | HCID 59401202 | 86% |
반응 단계
N-(3-Aminophenyl)acetamide (371 mg, 2.47 mmol), ethyl 2-bromo-2-phenylacetate (0.29 mL, 1.64 mmol), and DIPEA (0.43 mL, 2.47 mmol) are dissolved in acetonitrile (5 mL). The reaction is heated under MW irradiation at 100° C. for 30 minutes. Conversion complete by UPLC/MS-UV. Acetonitrile is evaporated and the crude residue is purified by flash chromatography (DCM/EtOAc=8/2) to obtain intermediate I92 as a colorless oil (440 mg, 86% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08835682B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_09 |
|---|
| ORD ID | ord-710f35955fd94a4ca0538bffada3a3b1 |
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| 출처 메모 | uspto-grants-2014_09 |
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