Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 76990생성일: 2026년 10월 25일
Benzenamine, 3-(methylthio)- → (3-Methylsulfanyl-phenylamino)-phenyl-acetic acid ethyl ester
https://huagongshe.com/reaction/76990
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Benzenamine, 3-(methylthio)- | HCID 15693 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | Ethyl bromophenylacetate | HCID 97780 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | (3-Methylsulfanyl-phenylamino)-phenyl-acetic acid ethyl ester | HCID 59401206 | 79% |
반응 단계
Ethyl 2-bromo-2-phenylacetate (0.22 mL, 1.23 mmol), 3-(methylthio)aniline (0.22 mL, 1.85 mmol), and DIPEA (0.32 mL, 1.85 mmol) are dissolved in acetonitrile (3 mL) and heated under microwave irradiation at 100° C. for 1 hour. Acetonitrile is evaporated and the crude residue is purified by flash chromatography (petroleum ether/EtOAc=85/15) to obtain intermediate I98 as a colorless oil (292 mg, 79% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08835682B2 |
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| 출처 데이터셋 | uspto-grants-2014_09 |
|---|
| ORD ID | ord-762ebd227668498f986026cf8361e129 |
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| 출처 메모 | uspto-grants-2014_09 |
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