참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2,5-Difluoroaniline | HCID 67775 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | Ethyl bromophenylacetate | HCID 97780 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | Ethyl 2-(2,5-difluorophenylamino)-2-phenylacetate | HCID 58556973 | 67% |
반응 단계
2,5-Difluoroaniline (0.19 mL, 1.85 mmol), ethyl 2-bromo-2-phenylacetate (0.22 mL, 1.23 mmol), and DIPEA (0.32 mL, 1.85 mmol) are dissolved in acetonitrile (3 mL) and heated under MW irradiation at 100° C. for 6 hours and then at 110° C. for 4 hours. Acetonitrile is evaporated and the crude is purified by flash chromatography (Petroleum ether/EtOAc=97/3) to obtain intermediate I104 as a white solid (240 mg, 67% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08835682B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_09 |
|---|
| ORD ID | ord-7adf7ece2fe84b79a4fb7b0fe2f787f8 |
|---|
| 출처 메모 | uspto-grants-2014_09 |
|---|
