Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Methoxyaniline → (3-Methoxy-phenylamino)-phenyl-acetic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Methoxyaniline | HCID 10824 | — |
| 반응물 | Bromo(phenyl)acetic acid | HCID 97919 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | (3-Methoxy-phenylamino)-phenyl-acetic acid | HCID 2759625 | 99% |
반응 단계
A solution of 2-bromo-2-phenylacetic acid (0.5 g, 2.28 mmol) and 3-methoxyaniline (0.54 mL, 4.56 mmol) in THF (12 mL) is refluxed for 4 hours. Solvent is removed under vacuum, the residue is taken up with 1M HCl and extracted with EtOAc. The organic phase is dried (Na2SO4), filtered and evaporated. The crude is purified by flash chromatography (DCM/MeOH=98/2 to 9/1) to obtain intermeaditae I116 as a white solid (0.58 g, 99% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08835682B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-d2075340269f4f199e1ba8a3ca303395 |
| 출처 메모 | uspto-grants-2014_09 |