N-(2-Amino-5-fluoro-phenyl)-5-bromo-2-chloro-benzamide → HCID 178505463, 화합물

반응식

[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[NH:9][C:10](=O)[C:11]1[CH:16]=[C:15]([Br:17])[CH:14]=[CH:13][C:12]=1[Cl:18]>C(O)(=O)C>[Br:17][C:15]1[CH:14]=[CH:13][C:12]([Cl:18])=[C:11]([C:10]2[NH:1][C:2]3[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=3[N:9]=2)[CH:16]=1

참가 물질

실험 절차

Method 3,4—Step b A solution of N-(2-Amino-5-fluoro-phenyl)-5-bromo-2-chloro-benzamide (6.90 g, 20.12 mmol) in acetic acid (40 mL) was stirred at 80° C. overnight, solvent was then removed under reduced pressure and the crude purified by precipitation from diethylether to obtain 6.00 g of the title compound (92%).

후처리

customsolvent was then removed under reduced pressure
customthe crude purified by precipitation from diethylether

출처 및 근거

ORD 기록: ord-ed40964a733b4b15a0823cfd54635c3f
출처 데이터셋: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08835648B2

반응 노트

불러오는 중…

참가 물질

반응물 1

HCID 63257336N-(2-Amino-5-fluoro-phenyl)-5-bromo-2-chloro-benzamide

생성물 1

HCID 178505463HCID 178505463, 화합물수율 92%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

후처리

customsolvent was then removed under reduced pressure
customthe crude purified by precipitation from diethylether

출처 및 근거

ORD 기록: ord-ed40964a733b4b15a0823cfd54635c3f
출처 데이터셋: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08835648B2

반응 노트

불러오는 중…