Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → N-(2-Amino-5-methoxy-phenyl)-5-bromo-2-fluoro-benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 5-Bromo-2-fluorobenzoic acid | HCID 2736315 | — |
| 반응물 | 4-Methoxybenzene-1,2-diamine dihydrochloride | HCID 3085161 | — |
| 반응물 | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N-(2-Amino-5-methoxy-phenyl)-5-bromo-2-fluoro-benzamide | HCID 63257662 | 62.4% |
반응 단계
Method 6—Step a A mixture of 5-Bromo-2-fluoro-benzoic acid (1.50 g, 6.85 mmol), 4-methoxy-benzene-1,2-diamine dihydrochloride (1.77 g, 8.49 mmol), HATU (2.73 g, 7.19 mmol) and TEA (2.88 mL, 20.76 mmol) in dichloromethane (20 mL) and DMF (5 mL) was stirred at room temperature overnight, then water was added (50 mL), mixture was stirred for 2 h and left standing at room temperature overnight. The precipitate obtained was filtered off and dried to afford 1.45 g of the title compound (50%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08835648B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-d73d945322a94c8a9a3b8a50b768d317 |
| 출처 메모 | uspto-grants-2014_09 |