Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → N-(2-Amino-5-chloro-phenyl)-5-bromo-2-fluoro-benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 4-Chloro-1,2-diaminobenzene | HCID 7263 | — |
| 반응물 | 5-Bromo-2-fluorobenzoic acid | HCID 2736315 | — |
| 반응물 | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N-(2-Amino-5-chloro-phenyl)-5-bromo-2-fluoro-benzamide | HCID 24699699 | 52% |
반응 단계
Method 7—Step a A mixture of 5-Bromo-2-fluoro-benzoic acid (3.00 g, 13.70 mmol), 4-chloro-benzene-1,2-diamine (2.42 g, 16.99 mmol), HATU (5.47 g, 14.38 mmol) and TEA (1.91 mL, 13.83 mmol) in dichloromethane (70 mL) and DMF (16 mL) was stirred at room temperature overnight, then water was added (80 mL) and left standing at room temperature overnight. The organic layer was divided and solvent removed under reduced pressure and the crude oil obtained was crystallized from the mixture of solvents dichloromethane:cyclohexane/3:1 (30 mL) to afford 2.19 g of the title compound (52%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08835648B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-b4ce010ef34c425eb8d782dbd571233d |
| 출처 메모 | uspto-grants-2014_09 |