참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1,3-Propanediamine, N1,N1,N3-trimethyl- | HCID 78302 | — |
| 반응물 | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| 반응물 | 1-[4-Chloro-3-(5-fluoro-1H-benzoimidazol-2-yl)-phenyl]-piperidine-4-carboxylic acid | HCID 178524547 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | HCID 178483532 | HCID 178483532 | 49% |
반응 단계
Method H—Step a To a vial with 1-[4-Chloro-3-(5-fluoro-1H-benzoimidazol-2-yl)-phenyl]-piperidine-4-carboxylic acid (obtained as described in general method 3,4, step e) (0.10 g, 0.26 mmol) and HATU (0.10 g, 0.27 mmol) in dichloromethane (2 mL), TEA (0.07 mL, 0.54 mmol) and N,N,N′-trimethyl-1,3-propanediamine (0.32 mmol, 0.05 mL) were added. The reaction mixture was heated at 35° C. overnight, solvent was removed and the crude was purified by PrepHPLC and SCX column to obtain 0.06 g of the title compound (49%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08835648B2 |
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| 출처 데이터셋 | uspto-grants-2014_09 |
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| ORD ID | ord-27ca3a58482c406992ccbeb17b6ca9cb |
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| 출처 메모 | uspto-grants-2014_09 |
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