Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzoyl Peroxide → 2-[4-(Bromomethyl)-3-(methoxymethoxy)phenyl]-1,3-benzoxazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzoyl Peroxide | HCID 7187 | — |
| 반응물 | N-bromobutanimide | HCID 67184 | — |
| 반응물 | 2-[3-(Methoxymethoxy)-4-methylphenyl]-1,3-benzoxazole | HCID 21991002 | — |
| 용매 | Carbon Tetrachloride | HCID 5943 | — |
| 생성물 | 2-[4-(Bromomethyl)-3-(methoxymethoxy)phenyl]-1,3-benzoxazole | HCID 21990942 | — |
반응 단계
A solution of 2-[3-(methoxymethoxy)-4-methylphenyl]-1,3-benzoxazole (200 mg, 0.74 mmol, 84%), NBS (179 mg, 0.81 mmol), and benzoyl peroxide (50 mg) in CCl4 (10 mL), was refluxed for 12 h. After cooling to rt, CCl4 was removed in vacuo and residue was purified by flash column (silica gel, hexanes:EtOAc 5:1) to afford 2-[4-(bromomethyl)-3-(methoxymethoxy)phenyl]-1,3-benzoxazole. MS (ESI) 349 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07087601B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-3fbdb02c28694b2ab3cd6d303a6d36e5 |
| 출처 메모 | uspto-grants-2006_08 |