Citric Acid → Escitalopram

HRID 77255

반응식

HRID 77255 반응식
C(O)(=O)CC(CC(O)=O)(C(O)=O)O.C(O)[C@H]1O[C@H](O[C@]2(CO)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@H](O)[C@@H](O)[C@@H]1O.COC([C@@H](NC([C@@H](N)CC(O)=O)=O)CC1C=CC=CC=1)=O.[CH3:58][N:59]([CH2:61][CH2:62][CH2:63][C@@:64]1([C:75]2[CH:76]=[CH:77][C:78]([F:81])=[CH:79][CH:80]=2)[O:72][CH2:71][C:70]2[CH:69]=[C:68]([C:73]#[N:74])[CH:67]=[CH:66][C:65]1=2)[CH3:60].C(O)(C(O)=O)=O>O.OCC(CO)O>[CH3:58][N:59]([CH2:61][CH2:62][CH2:63][C@@:64]1([C:75]2[CH:80]=[CH:79][C:78]([F:81])=[CH:77][CH:76]=2)[O:72][CH2:71][C:70]2[CH:69]=[C:68]([C:73]#[N:74])[CH:67]=[CH:66][C:65]1=2)[CH3:60]

참가 물질

7

반응물 4

HCID 311Citric AcidHCID 5988SucroseHCID 134601AspartameHCID 146571Escitalopram Oxalate

생성물 1

HCID 146570Escitalopram

시약·촉매·용매 2

HCID 753Glycerol용매HCID 962Water용매

실험 절차

The composition of the formulation and the amounts of the ingredients are shown in the table below. Citric acid was dissolved in 200 ml of distilled water and then sodium alginate (Protanal LF10/60, FMC Biopolymer), glycerol and sucrose were added and dissolved at 60° C. The obtained solution was cooled to ambient temperature and, then, Aspartame, Escitalopram Oxalate and Fantasy flavor were added and dissolved therein. The resulting solution was cast onto casting mold having casting area of 1,150 cm2 and dried according to Example 3.

후처리

  1. dissolutiondissolved at 60° C
  2. dissolutiondissolved
  3. customdried

출처 및 근거

ORD 기록
ord-e1b8f4cebdf942f3a50951d8c18284b7
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08840935B2

연결된 노트

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