1,3-Dibromopropane → 1-[4-(1,3-Benzoxazol-2-yl)-2-methoxyphenyl]cyclobutanecarbonitrile

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Utilizing the general procedure outlined in the synthesis of 2-[4-(1,3-benzoxazol-2-yl)-2-methoxyphenyl]propanenitrile, 4-(1,3-benzoxazol-2-yl)-2-methoxybenzonitrile (250 mg, 0.95 mmol) was reacted with 1,3-Dibromopropane (120 μL, 1.1 mmol) to afford the desired 1-[4-(1,3-benzoxazol-2-yl)-2-methoxyphenyl]cyclobutanecarbonitrile as a colorless solid: 1H NMR (CDCl3, 300 MHz) δ 7.89–7.87 (m, 3H), 7.62–7.55 (m, 1H) 7.39–7.36 (m, 2H), 7.32–7.26 (m, 1H), 4.05 (s, 3H), 2.90–2.83 (m, 2H), 2.67–2.47 (m, 4H). MS (ESI) 305 (M+H)+.

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