1,4-Dioxane hydrochloride → (R)-2-Methoxy-1-phenylethanamine hydrochloride
반응식
[ClH:1].O1CCOCC1.C(OC([NH:15][C@@H:16]([CH2:23][O:24][CH3:25])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=O)(C)(C)C>>[ClH:1].[CH3:25][O:24][CH2:23][C@H:16]([NH2:15])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1참가 물질
3
실험 절차
60 ml of 4N-HCl/dioxane solution was added to 4.02 g (16.0 mmols) of N-t-butoxycarbonyl-(R)-α-methoxymethylbenzylamine, and the mixture was stirred at room temperature for one hour. The reaction mixture was concentrated under reduced pressure. 30 ml of ether were added to the residue, and this was further concentrated to obtain (R)-α-methoxymethylbenzylamine hydrochloride in quantitative yield.
후처리
- concentrationThe reaction mixture was concentrated under reduced pressure
- addition30 ml of ether were added to the residue
- concentrationthis was further concentrated
출처 및 근거
- ORD 기록
- ord-3d062dc2d8ab4e1391656e4f536498a8
- 출처 데이터셋
- uspto-grants-1998_03
- 특허 번호
- US05723165
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