1,4-Dioxane hydrochloride → (R)-2-Methoxy-1-phenylethanamine hydrochloride

HRID 773

반응식

HRID 773 반응식
[ClH:1].O1CCOCC1.C(OC([NH:15][C@@H:16]([CH2:23][O:24][CH3:25])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=O)(C)(C)C>>[ClH:1].[CH3:25][O:24][CH2:23][C@H:16]([NH2:15])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

참가 물질

3

반응물 2

HCID 204431481,4-Dioxane hydrochlorideHCID 54257308N-t-butoxycarbonyl-(R)-alpha-methoxymethylbenzylamine

생성물 1

HCID 66589172(R)-2-Methoxy-1-phenylethanamine hydrochloride

실험 절차

60 ml of 4N-HCl/dioxane solution was added to 4.02 g (16.0 mmols) of N-t-butoxycarbonyl-(R)-α-methoxymethylbenzylamine, and the mixture was stirred at room temperature for one hour. The reaction mixture was concentrated under reduced pressure. 30 ml of ether were added to the residue, and this was further concentrated to obtain (R)-α-methoxymethylbenzylamine hydrochloride in quantitative yield.

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. addition30 ml of ether were added to the residue
  3. concentrationthis was further concentrated

출처 및 근거

ORD 기록
ord-3d062dc2d8ab4e1391656e4f536498a8
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05723165

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