p-Toluenesulfonic acid → HCID 70655408, 화합물

HRID 77340노트

반응식

HRID 77340 반응식
O[CH2:2][CH:3]1[CH2:7][O:6][C:5]2([CH2:12][CH2:11][N:10]([CH2:13][CH2:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH2:9][CH2:8]2)[O:4]1.[C:21]1(C)[CH:26]=[CH:25][C:24]([S:27](O)(=O)=O)=[CH:23][CH:22]=1.C1(S)C=CC=CC=1>C1(C)C=CC=CC=1>[CH2:13]([N:10]1[CH2:9][CH2:8][C:5]2([O:4][CH:3]([CH2:2][S:27][C:24]3[CH:25]=[CH:26][CH:21]=[CH:22][CH:23]=3)[CH2:7][O:6]2)[CH2:12][CH2:11]1)[CH2:14][C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

참가 물질

5

반응물 3

HCID 6101p-Toluenesulfonic acidHCID 7969ThiophenolHCID 667015182-Hydroxymethyl-8-phenethyl-1,4-dioxa-8-azaspiro[4,5]decane2회

생성물 1

HCID 70655408HCID 70655408, 화합물

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

2-hydroxymethyl-8-phenethyl-1,4-dioxa-8-azaspiro[4,5]decane (Compound 1, 50 gm, 0.18 mole) and Para Toluenesulfonic Acid (PTSA, 2 gm) were dissolved in toluene (350 ml) at room temperature. 20 gm of thiophenol was added drop wise to the above solution. The reaction was refluxed for 13 hrs at reflux temperature. The solvent was distilled off to get the light brown solid product with a melting point of 58° C. The yield of the product was 95%.

후처리

  1. temperatureThe reaction was refluxed for 13 hrs
  2. temperatureat reflux temperature
  3. distillationThe solvent was distilled off
  4. customto get the light brown solid product with a melting point of 58° C

출처 및 근거

ORD 기록
ord-054d4a7a395e4bf7aa1e7ee4c889894b
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08841296B2

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