2-Amino-4,6-dimethyl pyrimidine → HCID 178425977, 화합물

HRID 77344

반응식

HRID 77344 반응식
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([NH2:9])[N:3]=1.[NH2:10]O.[CH3:12][C:13]1[CH:18]=[C:17]([CH3:19])[CH:16]=[C:15]([CH3:20])[C:14]=1[S:21]([O-:24])(=[O:23])=[O:22]>C(Cl)Cl>[CH3:20][C:15]1[CH:16]=[C:17]([CH3:19])[CH:18]=[C:13]([CH3:12])[C:14]=1[S:21]([O-:24])(=[O:23])=[O:22].[NH2:10][N:3]1[C:2]([CH3:1])=[CH:7][C:6]([CH3:8])=[N:5][C:4]1=[NH2+:9]

참가 물질

4

반응물 2

HCID 130212-Amino-4,6-dimethyl pyrimidineHCID 19699281hydroxylamine 2,4,6-Trimethyl-benzenesulfonate

생성물 1

HCID 178425977HCID 178425977, 화합물수율 62%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

반응 조건

온도
0 °C

실험 절차

To a solution of 4,6-Dimethyl-pyrimidin-2-ylamine (25 g, 200 mmol) in 400 mL of CH2Cl2 was added dropwise a solution of hydroxylamine-2,4,6-Trimethyl-benzenesulfonate (105 g, 488 mmol) in 300 mL of CH2Cl2 at 0° C., and the mixture was stirred at 0° C. for 1 hand filtered. The solid collected was washed with CH2Cl2 (100 mL) to give 1-Amino-4,6-dimethyl-1H-pyrimidin-2-ylidene-ammonium 2,4,6-Trimethyl-benzenesulfonate (40 g, yield: 62%).

후처리

  1. filtrationfiltered
  2. customThe solid collected
  3. washwas washed with CH2Cl2 (100 mL)

출처 및 근거

ORD 기록
ord-add5d4ed43ad44c2b6d3159b4aec0f84
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08841297B2

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