Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 77365생성일: 2026년 10월 23일
1-(2-Fluorophenyl)piperazine → ethyl 1-(2-(4-(2-fluorophenyl)piperazin-1-yl)-2-iminoethyl)-5-methyl-1H-pyrrole-2-carboxylate
https://huagongshe.com/ko/reaction/77365
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1-(2-Fluorophenyl)piperazine | HCID 70529 | — |
| 반응물 | ethyl 1-(2-ethoxy-2-iminoethyl)-5-methyl-1H-pyrrole-2-carboxylate hydrochloride | HCID 86706663 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | ethyl 1-(2-(4-(2-fluorophenyl)piperazin-1-yl)-2-iminoethyl)-5-methyl-1H-pyrrole-2-carboxylate | HCID 86706665 | 85.4% |
반응 단계
A mixture of ethyl 1-(2-ethoxy-2-iminoethyl)-5-methyl-1H-pyrrole-2-carboxylate hydrochloride (950 mg, 3.46 mmol) and 1-(2-fluorophenyl)piperazine (1.87 g, 10.4 mmol) in ethanol (5 mL) was heated at 55° C. overnight. At this time, the reaction was concentrated in vacuo. Reverse phase column chromatography (0-100% acetonitrile/water) afforded ethyl 1-(2-(4-(2-fluorophenyl)piperazin-1-yl)-2-iminoethyl)-5-methyl-1H-pyrrole-2-carboxylate (1.1 g, 85.4%) as a white solid. LC-MS calcd. for C20H26N4O2 [(M+H)+] 373, obsd. 373.0.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08841299B2 |
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| 출처 데이터셋 | uspto-grants-2014_09 |
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| ORD ID | ord-dba85c6aabde48c7b3e8d9aed4842d64 |
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| 출처 메모 | uspto-grants-2014_09 |
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