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HCID 67115180, 화합물 → 2-amino-5-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-N-(2-(isopropylamino)-2-oxoethyl)benzamide

HRID 77374
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HRID 77374 반응식
[N:1]12[CH2:9][CH2:8][CH:5]([CH2:6][CH2:7]1)[N:4]([C:10]1[CH:11]=[CH:12][C:13]([N+:26]([O-])=O)=[C:14]([CH:25]=1)[C:15]([NH:17][CH2:18][C:19]([NH:21][CH:22]([CH3:24])[CH3:23])=[O:20])=[O:16])[CH2:3][CH2:2]2.[H][H]>CO.[Pd]>[NH2:26][C:13]1[CH:12]=[CH:11][C:10]([N:4]2[CH:5]3[CH2:8][CH2:9][N:1]([CH2:7][CH2:6]3)[CH2:2][CH2:3]2)=[CH:25][C:14]=1[C:15]([NH:17][CH2:18][C:19]([NH:21][CH:22]([CH3:24])[CH3:23])=[O:20])=[O:16]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 2

HCID 67115180HCID 67115180, 화합물2회HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 671150572-amino-5-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-N-(2-(isopropylamino)-2-oxoethyl)benzamide수율 98.9%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

5-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-N-(2-(isopropylamino)-2-oxoethyl)-2-nitrobenzamide (Intermediate 4A) (7.0 g, 18.0 mmol) was dissolved in methanol (120 mL) and palladium on carbon (0.7 g) added. The resulting solution was hydrogenated at room temperature under 4 bar pressure of hydrogen overnight. The reaction mixture was filtered through a celite pad, washed with methanol and dichloromethane, and concentrated to afford 2-amino-5-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-N-(2-(isopropylamino)-2-oxoethyl)benzamide (6.4 g, 17.8 mmol).

후처리

  1. filtrationThe reaction mixture was filtered through a celite pad
  2. washwashed with methanol and dichloromethane
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-9558f119a62d4df286cd3ab11e817182
출처 데이터셋
uspto-grants-2014_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08841289B2

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