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Water → N-((S)-6-Formyl-1,2,3,4-tetrahydronaphthalen-2-yl)-N-methyl-5-cyclopropylmethoxypyridine-2-carboxamide

HRID 77425
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인쇄 미리보기

반응식

HRID 77425 반응식
[CH3:1][N:2]([C@H:16]1[CH2:25][CH2:24][C:23]2[C:18](=[CH:19][CH:20]=[C:21]([CH:26]=C)[CH:22]=2)[CH2:17]1)[C:3]([C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH:13]2[CH2:15][CH2:14]2)=[CH:7][N:6]=1)=[O:4].CC([OH:31])C.O.I([O-])(=O)(=O)=O.[Na+]>C(=O)([O-])[O-].[Na+].[Na+].[Os](=O)(=O)(=O)=O>[CH:26]([C:21]1[CH:22]=[C:23]2[C:18](=[CH:19][CH:20]=1)[CH2:17][C@@H:16]([N:2]([CH3:1])[C:3]([C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH:13]3[CH2:15][CH2:14]3)=[CH:7][N:6]=1)=[O:4])[CH2:25][CH2:24]2)=[O:31]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 962WaterHCID 3776IsopropanolHCID 23667635Sodium periodateHCID 66663592N-methyl-N-((S)-6-vinyl-1,2,3,4-tetrahydronaphthalen-2-yl)-5-cyclopropylmethoxypyridine-2-carboxamide

생성물 1

HCID 86661275N-((S)-6-Formyl-1,2,3,4-tetrahydronaphthalen-2-yl)-N-methyl-5-cyclopropylmethoxypyridine-2-carboxamide

시약·촉매·용매 2

HCID 30318
Osmium Tetroxide
촉매
HCID 10340Sodium Carbonate용매

실험 절차

A mixture of N-methyl-N—((S)-6-vinyl-1,2,3,4-tetrahydronaphthalen-2-yl)-5-cyclopropylmethoxypyridine-2-carboxamide (1.40 g), 2-propanol (4 ml) and water (2 ml) was admixed with osmium(VIII) oxide (49 mg) and sodium metaperiodate (1.82 g), and the mixture was stirred for 12 hours. The reaction mixture was diluted with saturated sodium carbonate solution and extracted with ethyl acetate. The organic phase was dried over sodium sulfate, filtered and concentrated. The product was thus obtained with the molecular weight of 364.45 (C22H24N2O3); MS (ESI): 365 (M+H+).

후처리

  1. extractionextracted with ethyl acetate
  2. dry with materialThe organic phase was dried over sodium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated
  5. customThe product was thus obtained with the molecular weight of 364.45 (C22H24N2O3)

출처 및 근거

ORD 기록
ord-d405832cc9a34d8991d0b70915cde459
출처 데이터셋
uspto-grants-2014_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08841290B2

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