Triphenylphosphine → N-methyl-N-((S)-6-vinyl-1,2,3,4-tetrahydronaphthalen-2-yl)-5-cyclopropylmethoxypyridine-2-carboxamide

참여 물질

역할	이름	HCID	투입량
반응물	Triphenylphosphine	HCID 11776	—
반응물	Diisopropylethylamine	HCID 81531	—
반응물	Tri(butyl)vinyltin	HCID 53438229	—
반응물	N-((S)-6-Bromo-1,2,3,4-tetrahydronaphthalen-2-yl)-N-methyl-5-cyclopropylmethoxy-pyridine-2-carboxamide	HCID 66663511	—
촉매	palladium(II) acetate	HCID 167845	—
용매	Dimethylformamide	HCID 6228	—
생성물	N-methyl-N-((S)-6-vinyl-1,2,3,4-tetrahydronaphthalen-2-yl)-5-cyclopropylmethoxypyridine-2-carboxamide	HCID 66663592	—

반응 조건

온도	100 °C

반응 단계

A mixture of N—((S)-6-bromo-1,2,3,4-tetrahydronaphthalen-2-yl)-N-methyl-5-cyclopropylmethoxypyridine-2-carboxamide (1.50 g), tributylvinyltin (1.37 g), palladium(II) acetate (16 mg), triphenylphosphine (76 mg), diisopropylethylamine (8.5 ml) and DMF (20 ml) was heated to 100° C. for 12 hours. The cooled reaction mixture was partitioned between ethyl acetate and sodium carbonate solution. The organic phase was dried over sodium sulfate, filtered and concentrated. The residue was purified by chromatography on silica gel. The product was thus obtained with the molecular weight of 362.48 (C23H26N2O2); MS (ESI): 363 (M+H+).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08841290B2
출처 데이터셋	uspto-grants-2014_09
ORD ID	ord-1447899c35d14568b6be2f084ccabe3f
출처 메모	uspto-grants-2014_09