Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Imidazole → 2-[4-(1H-imidazol-1-ylmethyl)-3-methoxyphenyl]-1,3-benzoxazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Imidazole | HCID 795 | — |
| 반응물 | 2-[3-methoxy-4-(1H-1,2,3-triazol-1-ylmethyl)phenyl]-1,3-benzoxazole | HCID 10171825 | — |
| 반응물 | 2-[4-(Bromomethyl)-3-methoxyphenyl]-1,3-benzoxazole | HCID 21990991 | — |
| 생성물 | 2-[4-(1H-imidazol-1-ylmethyl)-3-methoxyphenyl]-1,3-benzoxazole | HCID 10286356 | — |
반응 단계
Utilizing the general procedure outlined for 2-[3-methoxy-4-(1H-1,2,3-triazol-1-ylmethyl)phenyl]-1,3-benzoxazole, reaction of 2-[4-(bromomethyl)-3-methoxyphenyl]-1,3-benzoxazole (300 mg, 1.0 mmol) and imidazole (70 mg, 1.0 mmol) afforded the desired 2-[4-(1H-imidazol-1-ylmethyl)-3-methoxyphenyl]-1,3-benzoxazole as a colorless solid: 1H NMR (CDCl3, 300 MHz) δ 7.57–7.86 (m, 6H), 7.26–7.40 (m, 4H), 5.53 (s, 2H), 4.02 (s, 3H). MS (ESI) 306 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07087601B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-06bb8c577a6e46ea8913149e21e959f7 |
| 출처 메모 | uspto-grants-2006_08 |