Cesium carbonate → 6-((2-((4-(trifluoromethoxy)phenyl)amino)pyrimidin-5-yl)methoxy)-3-((2-(trimethylsilyl)ethoxy)methyl)benzo[d]oxazol-2(3H)-one

HRID 77458노트

반응식

HRID 77458 반응식
[OH:1][C:2]1[CH:19]=[CH:18][C:5]2[N:6]([CH2:10][O:11][CH2:12][CH2:13][Si:14]([CH3:17])([CH3:16])[CH3:15])[C:7](=[O:9])[O:8][C:4]=2[CH:3]=1.C(=O)([O-])[O-].[Cs+].[Cs+].Cl[CH2:27][C:28]1[CH:29]=[N:30][C:31]([NH:34][C:35]2[CH:40]=[CH:39][C:38]([O:41][C:42]([F:45])([F:44])[F:43])=[CH:37][CH:36]=2)=[N:32][CH:33]=1>CN(C=O)C>[F:45][C:42]([F:43])([F:44])[O:41][C:38]1[CH:37]=[CH:36][C:35]([NH:34][C:31]2[N:30]=[CH:29][C:28]([CH2:27][O:1][C:2]3[CH:19]=[CH:18][C:5]4[N:6]([CH2:10][O:11][CH2:12][CH2:13][Si:14]([CH3:15])([CH3:16])[CH3:17])[C:7](=[O:9])[O:8][C:4]=4[CH:3]=3)=[CH:33][N:32]=2)=[CH:40][CH:39]=1

참가 물질

5

반응물 3

HCID 10796Cesium carbonateHCID 866797425-(chloromethyl)-N-(4-(trifluoromethoxy)phenyl)pyrimidin-2-amineHCID 86679744HCID 86679744, 화합물

생성물 1

HCID 866797456-((2-((4-(trifluoromethoxy)phenyl)amino)pyrimidin-5-yl)methoxy)-3-((2-(trimethylsilyl)ethoxy)methyl)benzo[d]oxazol-2(3H)-one수율 39%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of 6-hydroxy-3-((2-(trimethylsilyl)ethoxy)methyl)benzo[d]oxazol-2(3H)-one (0.093 g, 0.329 mmol) in DMF (4 mL) was add cesium carbonate (0.322 g, 0.988 mmol) and 5-(chloromethyl)-N-(4-(trifluoromethoxy)phenyl)pyrimidin-2-amine (0.1 g, 0.329 mmol). The reaction mixture was stirred at room temperature for 18 h. Solvent was removed under vacuum. The residue was dissolved in ethyl acetate, and washed with 10% NaOH solution, water, and brine. The organic layer was dried over anhydrous sodium sulfate, filtered, and concentrated. The crude product was purified by flash chromatography on silica gel using 20 to 80% ethyl acetate in hexanes to give 6-((2-((4-(trifluoromethoxy)phenyl)amino)pyrimidin-5-yl)methoxy)-3-((2-(trimethylsilyl)ethoxy)methyl)benzo[d]oxazol-2(3H)-one as an white solid (0.07 g, 39%). LCMS: RT 2.216 min; 529.2 [M−H].

후처리

  1. customSolvent was removed under vacuum
  2. dissolutionThe residue was dissolved in ethyl acetate
  3. washwashed with 10% NaOH solution, water, and brine
  4. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated
  7. customThe crude product was purified by flash chromatography on silica gel using 20 to 80% ethyl acetate in hexanes

출처 및 근거

ORD 기록
ord-d975a99e448f49cd8c4e88457209b2f9
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08841301B2

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