1,4-Dioxane hydrochloride → (1R)-2-ethoxy-1-phenylethan-1-amine hydrochloride

HRID 775

반응식

HRID 775 반응식
[ClH:1].O1CCOCC1.C(OC([NH:15][C@@H:16]([CH2:23][O:24][CH2:25][CH3:26])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=O)(C)(C)C>>[ClH:1].[CH2:25]([O:24][CH2:23][C@H:16]([NH2:15])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[CH3:26]

참가 물질

3

반응물 2

HCID 204431481,4-Dioxane hydrochlorideHCID 53739234N-t-butoxycarbonyl-(R)-alpha-ethoxymethylbenzylamine

생성물 1

HCID 70183214(1R)-2-ethoxy-1-phenylethan-1-amine hydrochloride

실험 절차

12.5 ml of 4N-HCl/dioxane solution were added to 0.66 g (2.5 mmols) of N-t-butoxycarbonyl-(R)-α-ethoxymethylbenzylamine, and the mixture was stirred at room temperature for one hour. The reaction mixture was concentrated under reduced pressure, 30 ml of ether was added to the residue, and this was further concentrated to obtain (R)-α-ethoxymethylbenzylamine hydrochloride at a quantitative yield.

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure, 30 ml of ether
  2. additionwas added to the residue
  3. concentrationthis was further concentrated

출처 및 근거

ORD 기록
ord-ae03dc6af35144969588f144b56bba80
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05723165

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