Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 3,5-Diamino-6-chloro-pyrazine acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate | HCID 73827 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 3,5-Diamino-6-chloro-pyrazine acid | HCID 6452119 | — |
반응 단계
A mixture of methyl 3,5-diamino-6-chloropyrazine-2-carboxylate (100 g; 494 mmol), methanol (1 L) and NaOH (6 mol/L in water; 240 mL; 1.44 mol) is refluxed for 3 h. The mixture is allowed to cool to room temperature and then neutralised by addition of hydrochloric acid (6 M in water; ca. 120 mL). Water (200 mL) is added. The precipitate formed is collected by filtration while applying suction, washed with water and dried at 60° C. Yield: 99.6 g (107% of theory).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08841309B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-1eeb9b6e8bfc462294df91890cc93ba8 |
| 출처 메모 | uspto-grants-2014_09 |