Diethyl Ether → 2-Amino-5-bromo-4-methoxybenzonitrile

HRID 77522노트

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HRID 77522 반응식
[NH2:1][C:2]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[Br:12]Br.C(OCC)C>O1CCOCC1>[NH2:1][C:2]1[CH:9]=[C:8]([O:10][CH3:11])[C:7]([Br:12])=[CH:6][C:3]=1[C:4]#[N:5]

참가 물질

5

반응물 3

HCID 3283Diethyl EtherHCID 24408BromineHCID 37231282-Amino-4-methoxybenzonitrile

생성물 1

HCID 574230422-Amino-5-bromo-4-methoxybenzonitrile수율 81%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

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온도
0 °C

실험 절차

2-Amino-4-methoxybenzonitrile (4.47 g, 30.2 mmol) is dissolved in 70 ml of dioxane and treated at 0° C. with bromine (1.71 ml, 33.2 mmol). It is subsequently stirred at 0° C. for one hour. After addition of diethyl ether, the resulting crystals are filtered off with suction. The desired product is obtained in 81% yield (5.52 g).

후처리

  1. filtrationthe resulting crystals are filtered off with suction

출처 및 근거

ORD 기록
ord-62bed51aad364d0ca402331d29457e73
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08841311B2

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