Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-benzyloxycarbonyl-beta-benzyl-L-aspartyl-D-isoleucine → alpha-L-aspartyl-D-isoleucine (R)-alpha-methoxymethylbenzylamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-benzyloxycarbonyl-beta-benzyl-L-aspartyl-D-isoleucine | HCID 54543031 | — |
| 반응물 | (R)-2-Methoxy-1-phenylethanamine hydrochloride | HCID 66589172 | — |
| 생성물 | alpha-L-aspartyl-D-isoleucine (R)-alpha-methoxymethylbenzylamide | HCID 53660612 | 22.1% |
반응 단계
The same process as in Example 15 was repeated, except that N-benzyloxycarbonyl-β-benzyl-L-aspartyl-D-isoleucine was used in place of N-benzyloxycarbonyl-β-benzyl-L-aspartyl-D-valine and that (R)-α-methoxymethylbenzylamine hydrochloride was used in place of (R)-α-ethoxymethylbenzylamine hydrochloride, and α-L-aspartyl-D-isoleucine (R)-α-methoxymethylbenzylamide was obtained as a solid product. The total yield was 22.1%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05723165 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-f6a778234f084513ae50b4ca3b6875a0 |
| 출처 메모 | uspto-grants-1998_03 |