Methanol → Methyl 3-iodo-5-nitrobenzoate

HRID 77745

반응식

HRID 77745 반응식
[I:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([N+:11]([O-:13])=[O:12])[CH:10]=1)[C:5]([OH:7])=[O:6].O=S(Cl)Cl.[CH3:18]O>>[CH3:18][O:6][C:5](=[O:7])[C:4]1[CH:8]=[C:9]([N+:11]([O-:13])=[O:12])[CH:10]=[C:2]([I:1])[CH:3]=1

참가 물질

4

반응물 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 805803-Iodo-5-nitrobenzoic acid

생성물 1

HCID 7020599Methyl 3-iodo-5-nitrobenzoate수율 99%

실험 절차

To a solution of 3-iodo-5-nitrobenzoic acid (20.00 g, 0.068 mol) in methanol (50 mL) was added SOCl2 (5.45 mL, 0.075 mol) at 0° C. The reaction mixture was allowed to warm to room temperature and was then heated to reflux for 2 hours. The reaction was cooled and solvent was removed in vacuo to afford 3-Iodo-5-nitro-benzoic acid methyl ester as light yellow solid (20.67 g, 99%). MS (M+H)=309.

후처리

  1. temperaturewas then heated
  2. temperatureto reflux for 2 hours
  3. temperatureThe reaction was cooled
  4. customsolvent was removed in vacuo

출처 및 근거

ORD 기록
ord-d65d0c56b3a741db8b2fc99bc7ff19ba
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08841336B2

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