Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 77786생성일: 2026년 10월 23일
Silicon tetrachloride → 3-(5-Chloro-pyridin-2-yl)-5-(5-isopropyl-tetrazol-1-yl)-benzoic acid methyl ester
https://huagongshe.com/ko/reaction/77786
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Silicon tetrachloride | HCID 24816 | — |
| 반응물 | Sodium Azide | HCID 33557 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | 3-(5-Chloro-pyridin-2-yl)-5-isobutyrylamino-benzoic acid methyl ester | HCID 57851430 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 3-(5-Chloro-pyridin-2-yl)-5-(5-isopropyl-tetrazol-1-yl)-benzoic acid methyl ester | HCID 57851604 | 90.1% |
반응 단계
3-(5-Chloro-pyridin-2-yl)-5-isobutyrylamino-benzoic acid methyl ester (1.90 g, 5.71 mmol) was dissolved in acetonitrile, and NaN3 (3.71 g, 5.71 mmol) and SiCl4 (1.64 mL, 14.28 mmol) were added. The reaction mixture was stirred at 60° C. for 18 hours, then cooled and poured in to cold saturated aqueous NaHCO3. The resulting mixture was extracted with EtOAc, and the combined organic layers were dried (MgSO4), filtered and concentrated under reduced pressure to give 1.84 g of 3-(5-chloro-pyridin-2-yl)-5-(5-isopropyl-tetrazol-1-yl)-benzoic acid methyl ester, MS (M+H)=358.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08841336B2 |
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| 출처 데이터셋 | uspto-grants-2014_09 |
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| ORD ID | ord-791513e75ff44e2d89be8018f7f5923e |
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| 출처 메모 | uspto-grants-2014_09 |
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