2-Aminophenol → 4-(Benzo[d]oxazol-2-yl)-2-methoxyphenol
반응식
[OH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][C:3]=1[O:11][CH3:12].[NH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1O>C[Si](OP(=O)=O)(C)C>[O:8]1[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=2[N:13]=[C:6]1[C:5]1[CH:9]=[CH:10][C:2]([OH:1])=[C:3]([O:11][CH3:12])[CH:4]=1참가 물질
4
반응 조건
- 온도
- 180 °C
실험 절차
4-hydroxy-3-methoxybenzoic acid (25 g, 150 mmol) and 2-amino phenol (16 g, 150 mmol) were combined in a round bottom flask. Trimethylsilyl polyphosphate (80 mL) was added. The mixture was heated at 180° C. for 30 min. The mixture was poured over ice and allowed to stir overnight. The suspension was filtered to afford 4-(1,3-benzoxazol-2-yl)-2-methoxyphenol as a pale green solid. MS (ESI) 242 (M+H).
후처리
- additionThe mixture was poured over ice
- filtrationThe suspension was filtered
출처 및 근거
- ORD 기록
- ord-e0ed6a9d85f54de885301c17ac0d5c45
- 출처 데이터셋
- uspto-grants-2006_08
- 특허 번호
- US07087601B2
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