Ammonia → 2-Amino-6-chloronicotinic acid

반응식

Cl[C:2]1[N:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[NH3:12]>>[NH2:12][C:2]1[N:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

참가 물질

반응물 2

HCID 222Ammonia

HCID 8540472,6-Dichloronicotinic acid

생성물 1

HCID 122639922-Amino-6-chloronicotinic acid수율 49%

반응 조건

온도: 135 °C

실험 절차

A mixture of 2,6-dichloro-nicotinic acid (31 g, 0.14 mol) and 28% aqueous ammonia solution (200 mL) was stirred in a sealed tube for 10 hours at 135° C. This reaction solution was cooled to room temperature, and the excess ammonia gas was removed under a reduced pressure. Water was added to the residue to a total of 1000 mL, the mixture was cooled to 0° C., and citric acid was added to a pH being about 6. The precipitated solids were filtered out to obtain the title compound (12 g, 49%).

후처리

temperatureThis reaction solution was cooled to room temperature
customthe excess ammonia gas was removed under a reduced pressure
additionWater was added to the residue to a total of 1000 mL
temperaturethe mixture was cooled to 0° C.
additioncitric acid was added to a pH
filtrationThe precipitated solids were filtered out

출처 및 근거

ORD 기록: ord-c6bcdac826aa4bd2aef409a03fd677ce
출처 데이터셋: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08841327B2

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