Sulfuric Acid → Methyl 2-amino-6-chloronicotinate

HRID 77845노트

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HRID 77845 반응식
S(=O)(=O)(O)O.[NH2:6][C:7]1[N:15]=[C:14]([Cl:16])[CH:13]=[CH:12][C:8]=1[C:9]([OH:11])=[O:10].[C:17](=O)([O-])O.[Na+]>CO>[CH3:17][O:10][C:9](=[O:11])[C:8]1[CH:12]=[CH:13][C:14]([Cl:16])=[N:15][C:7]=1[NH2:6]

참가 물질

5

반응물 3

HCID 1118Sulfuric AcidHCID 516892Sodium BicarbonateHCID 122639922-Amino-6-chloronicotinic acid

생성물 1

HCID 57415887Methyl 2-amino-6-chloronicotinate수율 68%

시약·촉매·용매 1

HCID 887Methanol용매

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온도
70 °C

실험 절차

Concentrated sulfuric acid (25 mL) and 2-amino-6-chloro-nicotinic acid (4.3 g, 25 mmol) described in Manufacturing Example 26-1-1 were added to methanol (50 mL) on an ice bath, and stirred at 70° C. for 5 hours. The reaction mixture was cooled and then neutralized by addition of aqueous sodium hydrogen carbonate (90 g) solution. The precipitated solids were filtered to obtain the title compound (3.2 g, 17 mmol, 68%).

후처리

  1. temperatureThe reaction mixture was cooled
  2. filtrationThe precipitated solids were filtered

출처 및 근거

ORD 기록
ord-18895427fbde43ce970f88e3db762416
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08841327B2

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