Thionyl Chloride → 5-Bromo-2-(chloromethyl)pyridine--hydrogen chloride (1/1)

HRID 77928

반응식

HRID 77928 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8]O)=[N:6][CH:7]=1.S(Cl)([Cl:12])=O>C1(C)C=CC=CC=1>[ClH:12].[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][Cl:12])=[N:6][CH:7]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 5200169(5-Bromopyridin-2-yl)methanol

생성물 1

HCID 534382005-Bromo-2-(chloromethyl)pyridine--hydrogen chloride (1/1)수율 69.2%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To a toluene (20.0 mL) solution of (5-bromo-pyridin-2-yl)-methanol (4.70 g, 25.0 mmol) described in Manufacturing Example 54-1-1 was added dropwise thionyl chloride (3.65 mL, 50.1 mmol) on an ice bath (0° C.) under nitrogen atmosphere, which was stirred for 5 minutes at room temperature. The solvent was evaporated under a reduced pressure to obtain the title compound (4.2 g, 69.2%) as a hydrochloride.

후처리

  1. customThe solvent was evaporated under a reduced pressure

출처 및 근거

ORD 기록
ord-af0f2de5e29f4673ac9136e79a08340c
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08841327B2

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