4-Hydroxybenzaldehyde → 4-Butoxybenzaldehyde

HRID 77975

반응식

HRID 77975 반응식
[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:17][CH2:18][CH2:19][CH3:20]>CN(C)C=O>[CH2:17]([O:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1)[CH2:18][CH2:19][CH3:20]

참가 물질

5

반응물 3

HCID 1264-HydroxybenzaldehydeHCID 8002Butyl bromideHCID 11430Potassium Carbonate

생성물 1

HCID 798134-Butoxybenzaldehyde수율 107.7%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

4-Hydroxybenzaldehyde (3 g, 24.6 mmol) and potassium carbonate (10.2 g, 73.8 mmol) were suspended in N,N-dimethylformamide (60 mL). 1-Bromobutane (3.17 mL, 29.5 mmol) was added to this suspension, and stirred for 17 hours at room temperature. The mixture was partitioned into ethyl acetate and water. The organic layer was separated, washed with water, dried over anhydrous magnesium sulfate, and filtered. The filtrate was concentrated under a reduced pressure to obtain the title compound (4.72 g).

후처리

  1. customThe mixture was partitioned into ethyl acetate and water
  2. customThe organic layer was separated
  3. washwashed with water
  4. dry with materialdried over anhydrous magnesium sulfate
  5. filtrationfiltered
  6. concentrationThe filtrate was concentrated under a reduced pressure

출처 및 근거

ORD 기록
ord-a523d84def9a4e21be1531f307b9aecf
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08841327B2

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