Ammonium Hydroxide → [2-(1-Methyl-pyrrolidin-yl)ethyl] thiourea

HRID 7812

반응식

HRID 7812 반응식
[N:1]([CH2:4][CH2:5][CH:6]1[CH2:10][CH2:9][CH2:8][N:7]1[CH3:11])=[C:2]=[S:3].[OH-].[NH4+:13]>>[CH3:11][N:7]1[CH2:8][CH2:9][CH2:10][CH:6]1[CH2:5][CH2:4][NH:1][C:2]([NH2:13])=[S:3]

참가 물질

3

반응물 2

HCID 14923Ammonium Hydroxide2회HCID 219923282-(2-Isothiocyanatoethyl)-1-methylpyrrolidine

생성물 1

HCID 21992305[2-(1-Methyl-pyrrolidin-yl)ethyl] thiourea

실험 절차

The 2-(2-isothiocyanatoethyl)-1-methylpyrrolidine and concentrated ammonium hydroxide (3 mL) were heated at 100° C. for 30 minutes. Additional ammonium hydroxide (1 mL) was added and heating was continued for an additional 30 minutes. The reaction mixture was allowed to cool to room temperature and then it was lyophilized to give [2-(1-methylpyrrolidin-2-yl)ethyl]thiourea as a very viscous colorless oil.

후처리

  1. temperatureheating

출처 및 근거

ORD 기록
ord-6c3f3afcea9a427b9b1ed5038ccd9a33
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087623B2

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